Polystyrene nanoplastics mediated the toxicity of silver nanoparticles in zebrafish embryos

The widespread distribution of nanoplastics and nanomaterials in aquatic environments is great concern. Nanoplastics have been found to modulate the toxicity other environmental pollutants organisms, while few studies focused on their influences nanomaterials. Thus, this study evaluated polystyrene (PS) silver nanoparticles (AgNPs) zebrafish ( Danio rerio ) embryos, including acute toxicity, oxidative stress, apoptosis, immunotoxicity, metabolic capability. results showed that presence PS could act as a carrier co-existing AgNPs waters. release ratio Ag + from was up 4.23%. lethal effects embryos were not significantly changed by co-added nanoplastics. Whereas, alterations gene expression related antioxidant capability sod1 , cat mt2 mtf-1 cox1 caused enhanced nanoplastics, which simultaneously lowered apoptosis immunotoxicity caspase9 nfkβ cebp il-1β induced AgNPs. It suggests suppressed AgNPs-induced genotoxicity zebrafish. released may be responsible for zebrafish, subsequent absorption agglomeration alleviate toxicity.